E-prescribing your practice โ€” and your partners โ€” can trust.

A single Surescripts-certified platform that handles EPCS, real-time benefit and formulary checks, and advanced AI capabilities.

HIPAA Compliant EPCS Ready 19+ Years
Product screenshot
AI, built into prescribing Explore โ†’

E-prescribing your practice - and your partners - can trust.

A single Surescripts-certified platform that handles EPCS, real-time benefit and formulary checks, and advanced AI capabilities - ready for prescribers today, and simple to integrate for EHR and health-tech partners.

Surescripts Certified HIPAA Compliant EHNAC Accredited 21 CFR Part 1311
Product screenshot

Trusted by practices & health-tech partners nationwide

EHR / EMR partner
Health system
Telehealth platform
Multi-site practice
Pharmacy network
Digital health brand
19+
Years in Market
100s of Millions
e-Prescriptions sent
50
States covered
99.95%
Platform uptime
Up to 70%
Prescriptions Supported

Trusted by physicians across the USA for 19+ years โ€” one of the earliest adopters of standalone e-prescribing.

The last mile of prescribing is broken

Scripts stall between the exam room and the pharmacy

Abandoned prescriptions, pharmacy transfers, and callback ping-pong cost practices time and patients their medications. H2H closes the gap at the point of prescribing.

Fewer abandons Real cost upfront

Patients see the price before they leave

Real-time benefit and lower-cost alternatives surface at the point of prescribing โ€” so sticker shock never sends a script to the shelf.

Fewer transfers Right pharmacy first

Route to the right pharmacy the first time

Patients pick their own pharmacy up front, and switching is just as easy if plans change โ€” so far fewer calls get rerouted or transferred elsewhere.

Less staff work Fewer callbacks

Resolve fill issues without clinical staff

Cancels, Rx changes, and refill authorizations happen electronically โ€” no phone tag between the front desk and the pharmacy.

Key Features

Built for Healthcare, Proven in Practice

Everything a prescriber needs to write, check, and manage a script โ€” in one workflow.

Rx

New Rx

Create and send first-time prescriptions in seconds, routed straight to the patientโ€™s pharmacy of choice.

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EPCS

EPCS

Prescribe controlled substances electronically with simplified MFA, fully compliant with 21 CFR Part 1311.

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ePA

Electronic Prior Authorization

Get patients on cost-effective, clinically appropriate medications faster, without the phone tag.

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RFL

Refill Rx

Authorize refills up front so patients can renew a valid prescription without another office visit.

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RxC

Cancel Rx & Rx Change

Cancel a prescription or swap medications instantly when a pharmacy canโ€™t fill it as written.

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AI

AI Prescription Agent

Type or speak the instruction and the agent handles the rest โ€” drafting and validating the prescription automatically, cutting the time providers spend writing scripts by up to 75%.

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RTPB

Real-Time Prescription Benefit

See patient-specific benefit and cost information before the script is sent, not after.

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RTF

Real-Time Formulary

Formulary status, payer alternatives, and co-pay details at the exact point of prescribing.

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Hx

Medication History

Full medication history with drug-drug, drug-allergy, and drug-food interaction checks.

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PDMP

PDMP

Check prescription drug monitoring program data right inside the prescribing workflow, with every lookup captured in a complete audit trail.

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New

AI-Powered Medication Adherence Prediction

Before you prescribe, H2H predicts a patient's likelihood of adhering to a medication โ€” and when that likelihood is low, our proprietary AI/ML algorithm surfaces why, from pharmacy deserts to complex prescription regimens, so you can act before the script is ever sent.

Explore AI Adherence โ†’
Adherence probability โ€” product screenshot
Now for patients too

A patient portal that guides every script home

The prescription doesnโ€™t end when itโ€™s sent. H2H gives patients a simple portal to find the right pharmacy, track their medications, and save money โ€” so fewer scripts are left behind.

Pharmacy finder Find in-network pharmacies ranked by distance and cost.
Medication tracker Patients see active scripts and refill status.
Savings options Surface lower-cost pharmacy and coupon paths.
Refill requests Request refills without calling the office.
Pickup guidance Clear next steps so fewer scripts are abandoned.
Explore the Patient Portal โ†’
Patient app โ€” pharmacy finder

Certified & Compliant

Surescripts Gold Certified HIPAA Compliant EHNAC P&S Accredited 21 CFR Part 1311 (EPCS)
Integration Models

Three ways to bring H2H into your workflow

Whichever way your practice or platform is set up, H2H fits without disrupting it.

SA

Stand-Alone Access

For prescribers without an EMR, EHR, or MAR system log in directly to send prescriptions at the point of care.

EMR

Embedded EMR / EHR / MAR

H2H opens from a โ€œprescribeโ€ link inside your existing system; authentication happens behind the scenes.

API

Web API (SOAP & REST)

Connect via H2Hโ€™s SOAP or REST web services, with webhooks for real-time status updates, to bring e-prescribing functionality directly into your own application.

Testimonials

Trusted by practices for two decades

"I have worked with H2H for over 15years. they have always provided a great product, at a good price, and when support services have been needed they provide great support."

Bea W. Dir of Systems integration Health, Wellness and Fitness

"My overall experience is a 10/10. I have no issues and I am extremely satisfied with Digital RX. [sensitive content hidden] in customer service is wonderful and I know if I ever have an issue I can call or email her and its revolved asap. As you know being a provider, time is everything so that alone is amazing."

Fahim Q. MD Mental Health Care
Why H2H

How H2H compares to DrFirst, DoseSpot, and RXNT

17+ years in e-prescribing, Surescripts Gold and White Coat honors, and an AI adherence capability none of them lead with yet.

19+ years, Gold-Certified

Surescripts Gold and White Coat Award recognition since 2007.

Full EPCS, Simplified MFA

21 CFR Part 1311 compliant without slowing prescribers down.

One Workflow

RTPB, real-time formulary, ePA, and PDMP together โ€” not bolted on.

AI Adherence Prediction

Predicts adherence risk and the reason behind it before a prescription is even written.

See H2H DigitalRx in your workflow

A 45-minute walkthrough, tailored to your practice or platform.

Request a Demo